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GSK3 alpha 抗体 (pSer21)

Name: GSK3 alpha 抗体 (pSer21)
SKU: ABIN708116
Availability: OutOfStock

GSK3a 适用: 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

Formalin-fixed and paraffin embedded rat brain labeled with Anti-phospho-GSK3 Alpha(Ser21) Polyclonal Antibody, Unconjugated (ABIN708116) at 1:200 followed by conjugation to the secondary antibody and DAB staining (GSK3 alpha 抗体 (pSer21))

IHC

ELISA

Lane 1: rat heart lysates Lane 2: rat brain lysates probed with Anti phospho-GSK3 Alpha(Ser21) Polyclonal Antibody, Unconjugated (ABIN708116) at 1:200 in 4 °C. (GSK3 alpha 抗体 (pSer21))

SDS

3 images

(1 reference)

产品编号 ABIN708116

发货至: 中国

Datasheet as PDF

抗原 See all GSK3 alpha (GSK3a) 抗体

GSK3 alpha (GSK3a) (Glycogen Synthase Kinase 3 alpha (GSK3a))
抗原表位
30

15

14

12

10

7

6

5

3

3

3

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1
pSer21
适用
96

80

63

5

5

3

3

2

2
小鼠, 大鼠
宿主
109

20

2
兔
Compatible Secondaries
克隆类型
109

24
多克隆
标记
74

10

8

7

4

4

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1
This GSK3 alpha antibody is un-conjugated
应用范围
105

60

56

18

17

14

12

12

7

3

3

2

2
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

特异性

This phosphorylation site is homologous to that of Ser21 in Mouse and Rat.

交叉反应

小鼠, 大鼠

预测反应

Human,Dog,Pig,Horse,Chicken

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic phosphopeptide derived from human GSK3 Alpha around the phosphorylation site of Ser21

亚型

IgG
anti-Glycogen Synthase Kinase 3 alpha (GSK3a) (pSer21) antibody
GSK3a 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Glycogen Synthase Kinase 3 alpha (GSK3a) antibody
KO Validated GSK3a 适用: 人 WB, IP 宿主: 兔 Monoclonal unconjugated

anti-Glycogen Synthase Kinase 3 alpha (GSK3a) (AA 122-406) antibody
GSK3a 适用: 小鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated

anti-Glycogen Synthase Kinase 3 alpha (GSK3a) (AA 76-105), (N-Term) antibody
GSK3a 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB3817-3818 unconjugated

anti-Glycogen Synthase Kinase 3 alpha (GSK3a) (AA 409-483) antibody
GSK3a 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Glycogen Synthase Kinase 3 alpha (GSK3a) antibody
GSK3a 适用: 人 WB, ELISA, ICC 宿主: 小鼠 Monoclonal 9D5G1 unconjugated

anti-Glycogen Synthase Kinase 3 alpha (GSK3a) antibody
GSK3a 适用: 人 WB, IHC, ELISA 宿主: 小鼠 Monoclonal 6G2F1 unconjugated

anti-Glycogen Synthase Kinase 3 alpha (GSK3a) (Ser21) antibody
GSK3a 适用: 人, 小鼠, 大鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Glycogen Synthase Kinase 3 alpha (GSK3a) (AA 36-118) antibody
GSK3a 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Glycogen Synthase Kinase 3 alpha (GSK3a) (AA 348-382) antibody
GSK3a 适用: 小鼠, 大鼠 WB 宿主: 兔 Polyclonal RB30809 unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Zhang, Zhao, Zhang, Hao, Yu, Min, Li, Ma, Chen, Yi, Tang, Meng, Liu, Wang, Shen, Zhang: "Decrease in male mouse fertility by hydrogen sulfide and/or ammonia can Be inheritable." in: Chemosphere, Vol. 194, pp. 147-157, (2018) (PubMed).
抗原

GSK3 alpha (GSK3a) (Glycogen Synthase Kinase 3 alpha (GSK3a))

别名

GSK3 Alpha (GSK3a 产品)

别名

2700086H06Rik antibody, GSK3A antibody, GSK-3[a] antibody, GSK-3[b] antibody, GSK3 antibody, gsk3a antibody, xgsk3 antibody, glycogen synthase kinase 3 alpha antibody, glycogen synthase kinase 3 alpha b antibody, glycogen synthase kinase 3 alpha S homeolog antibody, GSK3A antibody, Gsk3a antibody, gsk3a antibody, gsk3ab antibody, gsk3a.S antibody, Bm1_31380 antibody

背景

Synonyms: Glycogen synthase kinase-3 alpha, GSK-3 alpha, Serine/threonine-protein kinase GSK3A, GSK3A
Background: Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation.

基因ID

2931

UniProt

P49840

途径

PI3K-Akt Signaling, WNT signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, cAMP Metabolic Process, Cellular Glucan Metabolic Process, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, BCR Signaling, Warburg Effect