Synonyms:Deubiquitinating enzyme 22, KIAA1063, Ubiquitin thiolesterase 22, USP22, USP3L Background:Histone deubiquitinating component of the transcription regulatory histone acetylation(HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.