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背景
Synonyms:Tubby like protein 3, Tubby related protein 3, TUBL3, TULP3 Background:Negative regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with the IFT complex A(IFT-A) and is required for recruitment of G protein-coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide(phosphoinositide) lipids. Both IFT-A-and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. Not involved in ciliogenesis.