Synonyms:TRMT5, tRNA methyltransferase 5, TRM5, tRNA [GM37] methyltransferase, M1G methyltransferase Background:Involved in mitochondrial tRNA methylation(PubMed:26189817). Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine(yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.