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TRAIP 抗体

TRAIP 适用: 人, 小鼠 ELISA, IHC, WB, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7120031
发货至: 中国
  • 抗原 See all TRAIP 抗体
    TRAIP (TRAF Interacting Protein (TRAIP))
    适用
    • 19
    • 1
    • 1
    人, 小鼠
    宿主
    • 14
    • 4
    • 1
    克隆类型
    • 16
    • 3
    多克隆
    标记
    • 12
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TRAIP antibody is un-conjugated
    应用范围
    • 10
    • 7
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF)
    纯化方法
    Immunogen affinity purified
    纯度
    ≥95 % as determined by SDS-PAGE
    免疫原
    TRAF interacting protein
    亚型
    IgG
    Top Product
    Discover our top product TRAIP Primary Antibody
  • 应用备注
    WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:10-1:100
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    有效期
    12 months
  • 抗原
    TRAIP (TRAF Interacting Protein (TRAIP))
    别名
    TRAIP (TRAIP 产品)
    别名
    MGC81341 antibody, RNF206 antibody, TRIP antibody, Trip antibody, TRAF interacting protein antibody, TRAF interacting protein L homeolog antibody, TRAF-interacting protein antibody, TRAIP antibody, traip.L antibody, Traip antibody
    背景
    Synonyms:RNF206, TRIP Background:E3 ubiquitin ligase acting as a negative regulator of innate immune signaling. Inhibits activation of NF-kappa-B mediated by TNF. Negatively regulates TLR3/4-and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation(By similarity)(PubMed:22945920). Involved in response to genotoxic lesions during genome replication. Promotes H2AX and RPA2 phosphorylation after replication-associated DNA damage and assists fork progression at UV-induced replication-blocking lesions during S phase(PubMed:26595769). Has also been proposed to play a role in promoting translesion synthesis by mediating the assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN in order to facilitate bypass of DNA lesions and preserve genomic integrity(PubMed:24553286). The function in translesion synthesis is controversial(PubMed:26595769).
    分子量
    53 kDa
    基因ID
    10293
    UniProt
    Q9BWF2
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