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TSPAN12 抗体

TSPAN12 适用: 人, 大鼠, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7119860
发货至: 中国
  • 抗原 See all TSPAN12 抗体
    TSPAN12 (Tetraspanin 12 (TSPAN12))
    适用
    • 42
    • 22
    • 7
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    人, 大鼠, 小鼠
    宿主
    • 42
    克隆类型
    • 42
    多克隆
    标记
    • 16
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TSPAN12 antibody is un-conjugated
    应用范围
    • 23
    • 21
    • 13
    • 13
    • 7
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    纯化方法
    Immunogen affinity purified
    纯度
    ≥95 % as determined by SDS-PAGE
    免疫原
    tetraspanin 12
    亚型
    IgG
    Top Product
    Discover our top product TSPAN12 Primary Antibody
  • 应用备注
    WB: 1:200-1:2000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    有效期
    12 months
  • 抗原
    TSPAN12 (Tetraspanin 12 (TSPAN12))
    别名
    TSPAN12 (TSPAN12 产品)
    别名
    tm4sf12 antibody, zgc:63880 antibody, EVR5 antibody, NET-2 antibody, NET2 antibody, TM4SF12 antibody, 9030619E17 antibody, AI426782 antibody, AI663988 antibody, AW111457 antibody, Tm4sf12 antibody, tetraspanin-7 antibody, tetraspanin 12 antibody, LOC412465 antibody, TSPAN12 antibody, tspan12 antibody, Tspan12 antibody
    背景
    Synonyms:NET 2, NET2, Tetraspan NET 2, tetraspanin 12, TM4SF12, Tspan 12, TSPAN12 Background:Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin(NDP) signal transduction. Acts in concert with norrin(NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin(CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin(NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin(CTNNB1)(By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein(APP). Activates MMP14/MT1-MMP-dependent cleavage activity.
    分子量
    28 kDa
    基因ID
    23554
    UniProt
    O95859
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