TSPAN12 抗体
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- 抗原 See all TSPAN12 抗体
- TSPAN12 (Tetraspanin 12 (TSPAN12))
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适用
- 人, 大鼠, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This TSPAN12 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95 % as determined by SDS-PAGE
- 免疫原
- tetraspanin 12
- 亚型
- IgG
- Top Product
- Discover our top product TSPAN12 Primary Antibody
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- 应用备注
- WB: 1:200-1:2000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
- 有效期
- 12 months
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- 抗原
- TSPAN12 (Tetraspanin 12 (TSPAN12))
- 别名
- TSPAN12 (TSPAN12 产品)
- 别名
- tm4sf12 antibody, zgc:63880 antibody, EVR5 antibody, NET-2 antibody, NET2 antibody, TM4SF12 antibody, 9030619E17 antibody, AI426782 antibody, AI663988 antibody, AW111457 antibody, Tm4sf12 antibody, tetraspanin-7 antibody, tetraspanin 12 antibody, LOC412465 antibody, TSPAN12 antibody, tspan12 antibody, Tspan12 antibody
- 背景
- Synonyms:NET 2, NET2, Tetraspan NET 2, tetraspanin 12, TM4SF12, Tspan 12, TSPAN12 Background:Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin(NDP) signal transduction. Acts in concert with norrin(NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin(CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin(NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin(CTNNB1)(By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein(APP). Activates MMP14/MT1-MMP-dependent cleavage activity.
- 分子量
- 28 kDa
- 基因ID
- 23554
- UniProt
- O95859
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