cb437 antibody, wu:fb38c11 antibody, AA408947 antibody, BB081708 antibody, Itm1 antibody, ITM1 antibody, STT3-A antibody, TMC antibody, STT3A, subunit of the oligosaccharyltransferase complex (catalytic) antibody, STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae) antibody, STT3A, catalytic subunit of the oligosaccharyltransferase complex antibody, stt3a antibody, Stt3a antibody, STT3A antibody
背景
Synonyms:B5, Integral membrane protein 1, ITM1, STT3 A, STT3A, TMC, Transmembrane protein TMC Background:Catalytic subunit of the N-oligosaccharyl transferase(OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum(ER). SST3A seems to be involved in complex substrate specificity. STT3A is present in the majority of OST complexes and mediates cotranslational N-glycosylation of most sites on target proteins, while STT3B-containing complexes are required for efficient cotranslational glycosylation and mediate glycosylation of sites that have been skipped by STT3A.