4933419D20Rik antibody, AA986696 antibody, BIGM103 antibody, Zip8 antibody, LZT-Hs6 antibody, ZIP8 antibody, solute carrier family 39 (metal ion transporter), member 8 antibody, solute carrier family 39 member 8 antibody, Slc39a8 antibody, SLC39A8 antibody
背景
Synonyms:BIGM103, PP3105, SLC39A8, ZIP 8, ZIP8 Background:SLC39A8 also known as ZIP8 belongs to the ZIP family of metal ion transporters which function to transport zinc and/or other metal ion substrates from the extracellular space or organellar lumen into the cytoplasm. Recently it was found that Zip8 expression is upregulated in human monocytes in response to LPS, TNF-α, and live bacteria, facilitating cytoprotection during the early inflammation. Besides zinc ZIP8 can also transport cadmium and manganese efficiently. It is predicted that ZIP8 contains 3 potential N-linked glycosylation sites and is subject to glycosylation, which may account for the presences of multiple molecular weights, such as 43 kDa, 49 kDa, 60 kDa, 75-90 kDa, 150 kDa, and 200 kDa.