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SH2D1A 抗体

SH2D1A 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7119006
发货至: 中国
  • 抗原 See all SH2D1A 抗体
    SH2D1A (SH2 Domain Containing 1A (SH2D1A))
    适用
    • 53
    • 24
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    人, 小鼠, 大鼠
    宿主
    • 49
    • 3
    • 1
    • 1
    克隆类型
    • 53
    • 1
    多克隆
    标记
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    This SH2D1A antibody is un-conjugated
    应用范围
    • 43
    • 18
    • 13
    • 4
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    纯化方法
    Immunogen affinity purified
    纯度
    ≥95 % as determined by SDS-PAGE
    免疫原
    SH2 domain protein 1A
    亚型
    IgG
    Top Product
    Discover our top product SH2D1A Primary Antibody
  • 应用备注
    WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3 ,
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    有效期
    12 months
  • 抗原
    SH2D1A (SH2 Domain Containing 1A (SH2D1A))
    别名
    SH2D1A (SH2D1A 产品)
    别名
    DSHP antibody, EBVS antibody, IMD5 antibody, LYP antibody, MTCP1 antibody, SAP antibody, SAP/SH2D1A antibody, XLP antibody, XLPD antibody, RGD1562408 antibody, Gm686 antibody, SH2D1A antibody, SH2 domain containing 1A antibody, SH2D1A antibody, Sh2d1a antibody
    背景
    Synonyms:DSHP, SAP Background:This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.
    分子量
    17 kDa
    基因ID
    4068
    UniProt
    O60880
    途径
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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