AA516740 antibody, BC035291 antibody, KMT2G antibody, mKIAA1076 antibody, Set1B antibody, im:7156157 antibody, si:dkey-237o15.4 antibody, setd1b antibody, SET domain containing 1B antibody, SET domain containing 1B, a antibody, SET domain containing 1B S homeolog antibody, Setd1b antibody, SETD1B antibody, setd1ba antibody, setd1b.S antibody
背景
Synonyms:KIAA1076, KMT2G, SET1B Background:Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase(HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro.