电话:
+86 (0512) 65829739
传真:
+86 (010) 6788 5057
电子邮件:
orders@antibodies-online.cn

RNPS1 抗体

RNPS1 适用: 人, 小鼠, 大鼠 WB, ELISA, IP, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7118717
发货至: 中国
  • 抗原 See all RNPS1 抗体
    RNPS1 (RNA-Binding Protein S1 (RNPS1))
    适用
    人, 小鼠, 大鼠
    宿主
    • 3
    • 3
    克隆类型
    • 4
    • 2
    多克隆
    标记
    • 6
    This RNPS1 antibody is un-conjugated
    应用范围
    Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF)
    纯化方法
    Immunogen affinity purified
    纯度
    ≥95 % as determined by SDS-PAGE
    免疫原
    RNA binding protein S1, serine-rich domain
    亚型
    IgG
    Top Product
    Discover our top product RNPS1 Primary Antibody
  • 应用备注
    WB: 1:500-1:2000, IP: 1:200-1:1000, IF: 1:20-1:200
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    有效期
    12 months
  • 抗原
    RNPS1 (RNA-Binding Protein S1 (RNPS1))
    别名
    RNPS1 (RNPS1 产品)
    别名
    E5.1 antibody, ribonucleic acid binding protein S1 antibody, RNA binding protein with serine rich domain 1 antibody, RNA binding protein S1, serine-rich domain antibody, Rnps1 antibody, RNPS1 antibody
    背景
    Synonyms:LDC2 Background:Part of pre-and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex(EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner. Involved in the splicing modulation of BCL2L1/Bcl-X(and probably other apoptotic genes), specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S), the activity is different from the established EJC assembly and function. Participates in mRNA 3'-end cleavage. Involved in UPF2-dependent nonsense-mediated decay(NMD) of mRNAs containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds spliced mRNA 20-25 nt upstream of exon-exon junctions.
    分子量
    55-60 kDa
    基因ID
    10921
    UniProt
    Q15287
You are here:
客服