PLK2 抗体
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- 抗原 See all PLK2 抗体
- PLK2 (Polo-Like Kinase 2 (PLK2))
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PLK2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunoprecipitation (IP)
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95 % as determined by SDS-PAGE
- 免疫原
- polo-like kinase 2(Drosophila)
- 亚型
- IgG
- Top Product
- Discover our top product PLK2 Primary Antibody
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anti-Polo-Like Kinase 2 (PLK2) (C-Term) antibody
PLK2 适用: 人, 小鼠, 大鼠 WB, IHC (p), ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Polo-Like Kinase 2 (PLK2) (AA 322-671) antibodyPLK2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Polo-Like Kinase 2 (PLK2) (AA 666-685), (C-Term) antibodyPLK2 适用: 人, 大鼠 WB, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Polo-Like Kinase 2 (PLK2) (AA 375-406), (C-Term) antibodyPLK2 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB0873 unconjugated
anti-Polo-Like Kinase 2 (PLK2) (AA 585-685) antibodyPLK2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Polo-Like Kinase 2 (PLK2) (Internal Region) antibodyPLK2 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Polo-Like Kinase 2 (PLK2) (AA 1268-1341) antibodyPLK2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Polo-Like Kinase 2 (PLK2) (AA 336-685) antibodyPLK2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Polo-Like Kinase 2 (PLK2) (Internal Region) antibodyPLK2 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Polo-Like Kinase 2 (PLK2) (AA 261-310) antibodyPLK2 适用: 人, 小鼠, 大鼠, 豚鼠, 马, Cow, 犬, 斑马鱼, 兔, 非洲爪蟾, Hamster, 猴, Bat, Pig, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:500-1:2000, IP: 1:200-1:2000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
- 有效期
- 12 months
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- 抗原
- PLK2 (Polo-Like Kinase 2 (PLK2))
- 别名
- PLK2 (PLK2 产品)
- 别名
- SNK antibody, hPlk2 antibody, hSNK antibody, Snk antibody, PLK2 antibody, Plx2 antibody, MGC53990 antibody, plk2 antibody, zgc:165644 antibody, polo like kinase 2 antibody, polo-like kinase 2 antibody, polo-like kinase 2 L homeolog antibody, polo-like kinase 2b (Drosophila) antibody, Serine/threonine-protein kinase plk-2 antibody, PLK2 antibody, Plk2 antibody, plk2.L antibody, plk2b antibody, plk2 antibody, plk-2 antibody
- 背景
- Synonyms:SNK Background:Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CENPJ and NPM1, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress.
- 分子量
- 75-80 kDa
- UniProt
- Q9NYY3
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