PLCD4 antibody, PLCL3 antibody, si:dkeyp-84a8.7 antibody, 4921507K24Rik antibody, phospholipase C eta 1 antibody, phospholipase C delta 4 antibody, phospholipase C, delta 4a antibody, phospholipase C, delta 4 antibody, phospholipase C delta 4 L homeolog antibody, PLCH1 antibody, PLCD4 antibody, plcd4a antibody, plcd4 antibody, Plcd4 antibody, plcd4.L antibody
背景
Synonyms: Background:Hydrolyzes the phosphatidylinositol 4,5-bisphosphate(PIP2) to generate 2 second messenger molecules diacylglycerol(DAG) and inositol 1,4,5-trisphosphate(IP3). DAG mediates the activation of protein kinase C(PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.