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PHF2 抗体

This anti-PHF2 antibody is a 兔 多克隆 antibody detecting PHF2 in WB, ELISA, IHC 和 IP. Suitable for 人.
产品编号 ABIN7117376
发货至: 中国

Quick Overview for PHF2 抗体 (ABIN7117376)

抗原

See all PHF2 抗体
PHF2 (PHD Finger Protein 2 (PHF2))

适用

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宿主

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克隆类型

  • 13
  • 2
多克隆

标记

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This PHF2 antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)
  • 纯化方法

    Immunogen affinity purified

    纯度

    ≥95 % as determined by SDS-PAGE

    免疫原

    PHD finger protein 2

    亚型

    IgG
  • 应用备注

    WB: 1:200-1:1000, IP: 1:500-1:1000, IHC: 1:20-1:200

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

    有效期

    12 months
  • 抗原

    PHF2 (PHD Finger Protein 2 (PHF2))

    别名

    PHF2

    背景

    Synonyms:GRC5, JHDM1E, KIAA0662, PHD finger protein 2, PHF2 Background:Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3(H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3(H3K4me3) at rDNA promoters and promotes expression of rDNA.

    分子量

    100 kDa, 150 kDa

    基因ID

    5253

    UniProt

    O75151
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