USP52 antibody, 1200014O24Rik antibody, AI047843 antibody, AW742773 antibody, Usp52 antibody, mKIAA0710 antibody, PAN2 antibody, pan2 antibody, PAN2 poly(A) specific ribonuclease subunit antibody, PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae) antibody, PAN2 poly(A) specific ribonuclease subunit S homeolog antibody, PAN2 antibody, Pan2 antibody, pan2.S antibody
背景
Synonyms:KIAA0710, USP52 Background:Catalytic subunit of the poly(A)-nuclease(PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein(PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.