MCC 抗体
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- 抗原 See all MCC 抗体
- MCC (Mutated in Colorectal Cancers (MCC))
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This MCC antibody is un-conjugated
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应用范围
- ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95 % as determined by SDS-PAGE
- 免疫原
- mutated in colorectal cancers
- 亚型
- IgG
- Top Product
- Discover our top product MCC Primary Antibody
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anti-Mutated in Colorectal Cancers (MCC) (AA 1-829) antibody
MCC 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Mutated in Colorectal Cancers (MCC) (AA 31-130) antibodyMCC 适用: 人 ELISA, WB, RNAi 宿主: 小鼠 Monoclonal 1A7 unconjugated
anti-Mutated in Colorectal Cancers (MCC) (AA 479-611) antibodyMCC 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Mutated in Colorectal Cancers (MCC) (Center) antibodyMCC 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Mutated in Colorectal Cancers (MCC) (AA 31-130) antibodyMCC 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
anti-Mutated in Colorectal Cancers (MCC) (AA 1-829) antibodyMCC 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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- 应用备注
- WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:20-1:200
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
- 有效期
- 12 months
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- 抗原
- MCC (Mutated in Colorectal Cancers (MCC))
- 别名
- MCC (MCC 产品)
- 别名
- MCC antibody, mcc1 antibody, MCC1 antibody, D18Ertd451e antibody, E330037C19 antibody, RGD1561988 antibody, mutated in colorectal cancers antibody, MCC antibody, mcc antibody, Mcc antibody
- 背景
- Synonyms: Background:Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase(PAK) activation(PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway(canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin(CTNB1) transcriptional activity(PubMed:24824780).
- 分子量
- 98 kDa , 113-118 kDa
- 基因ID
- 4163
- UniProt
- P23508
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