MUL1 抗体
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- 抗原 See all MUL1 抗体
- MUL1 (Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1))
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This MUL1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95 % as determined by SDS-PAGE
- 免疫原
- mitochondrial E3 ubiquitin ligase 1
- 亚型
- IgG
- Top Product
- Discover our top product MUL1 Primary Antibody
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anti-Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1) (AA 45-95) antibody
MUL1 适用: 人, 小鼠, 大鼠 WB, IF (p), FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1) antibodyMUL1 适用: 人, 小鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1) (Middle Region) antibodyMUL1 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, 兔, Cow WB 宿主: 兔 Polyclonal unconjugated
anti-Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1) (AA 176-210) antibodyMUL1 适用: 人 WB 宿主: 兔 Polyclonal RB49942 unconjugated
anti-Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1) (AA 1-352) antibodyMUL1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1) (AA 143-192) antibodyMUL1 适用: 人, 小鼠, 犬, 豚鼠, 马, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1) (AA 216-265) antibodyMUL1 适用: 人, 犬, 豚鼠, 马, 兔, Cow, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1) (AA 1-352) antibodyMUL1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:500-1:2000, IHC: 1:20-1:200
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
- 有效期
- 12 months
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- 抗原
- MUL1 (Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1))
- 别名
- MUL1 (MUL1 产品)
- 背景
- Synonyms:C1orf166, GIDE, MAPL, MULAN, RNF218 Background:Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation. Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. The function may implicate its ability to sumoylate DNM1L. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response. Can mediate DDX58 sumoylation and disrupt its polyubiquitination.
- 分子量
- 35 kDa
- 基因ID
- 79594
- UniProt
- Q969V5
- 途径
- Positive Regulation of Endopeptidase Activity
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