Rkhd2 antibody, RKHD2 antibody, rkhd2 antibody, bm-013 antibody, rnf194 antibody, MEX-3C antibody, RNF194 antibody, A130001D14Rik antibody, BC035207 antibody, BM-013 antibody, mex-3 RNA binding family member C antibody, mex3 RNA binding family member C antibody, Mex3c antibody, MEX3C antibody, mex3c antibody
背景
Synonyms:RKHD2, RNF194 Background:E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation.