CG11098 antibody, Dmel\\CG11098 antibody, TANGO1 antibody, MIA3 antibody, 9130229H14Rik antibody, A930039G15Rik antibody, AU022327 antibody, B230399H06Rik antibody, C80126 antibody, Gm1525 antibody, Tango antibody, ARNT antibody, D320 antibody, TANGO antibody, UNQ6077 antibody, Transport and Golgi organization 1 antibody, MIA family member 3, ER export factor antibody, melanoma inhibitory activity family, member 3 antibody, melanoma inhibitory activity protein 3 antibody, melanoma inhibitory activity family member 3 antibody, melanoma inhibitory activity 3 antibody, Tango1 antibody, MIA3 antibody, LOC100055507 antibody, mia3 antibody, Mia3 antibody
背景
Synonyms:KIAA0268, TANGO, TANGO1 Background:Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII(COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum(PubMed:27138255).