RGD1306683 antibody, wu:fb92d03 antibody, wu:fd15e07 antibody, 3110040D16RIK antibody, MGC98945 antibody, LARP antibody, 1810024J12Rik antibody, 3110040D16Rik antibody, Larp antibody, mKIAA0731 antibody, La ribonucleoprotein domain family, member 1 antibody, La ribonucleoprotein domain family member 1 antibody, La ribonucleoprotein domain family member 1 L homeolog antibody, Larp1 antibody, larp1 antibody, LARP1 antibody, larp1.L antibody
背景
Synonyms:KIAA0731, LARP Background:RNA-binding protein that promotes translation of specific classes of mRNAs downstream of the mTORC1 complex. Associates with the mRNA 5'cap in an MTOR-dependent manner and associates with mRNAs containing a 5' terminal oligopyrimidine(5'TOP) motif, which is present in mRNAs encoding for ribosomal proteins and several components of the translation machinery. Associates with actively translating ribosomes via interaction with PABPC1/PABP and stimulates translation of mRNAs containing a 5'TOP, thereby regulating cell growth and proliferation. Positively regulates the replication of dengue virus(DENV)(PubMed:26735137).