zgc:76933 antibody, 1810045K06Rik antibody, D330008A20 antibody, mKIAA0469 antibody, RGD1305863 antibody, kelch-like family member 21 antibody, kelch like family member 21 antibody, kelch like family member 21 L homeolog antibody, kelch-like 21 antibody, klhl21 antibody, KLHL21 antibody, klhl21.L antibody, Klhl21 antibody
背景
Synonyms:KIAA0469 Background:Substrate-specific adapter of a BCR(BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex(CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.