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KPNA5 抗体

KPNA5 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7115574
发货至: 中国
  • 抗原 See all KPNA5 抗体
    KPNA5 (Karyopherin alpha 5 (Importin alpha 6) (KPNA5))
    适用
    • 26
    • 6
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 25
    • 1
    克隆类型
    • 25
    • 1
    多克隆
    标记
    • 16
    • 2
    • 2
    • 2
    • 2
    • 2
    This KPNA5 antibody is un-conjugated
    应用范围
    • 25
    • 18
    • 6
    • 4
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), ELISA
    纯化方法
    Immunogen affinity purified
    纯度
    ≥95 % as determined by SDS-PAGE
    免疫原
    karyopherin alpha 5(importin alpha 6)
    亚型
    IgG
    Top Product
    Discover our top product KPNA5 Primary Antibody
  • 应用备注
    WB: 1:500-1:2000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    有效期
    12 months
  • 抗原
    KPNA5 (Karyopherin alpha 5 (Importin alpha 6) (KPNA5))
    别名
    KPNA5 (KPNA5 产品)
    别名
    IPOA6 antibody, SRP6 antibody, Ipoa6 antibody, im:7151662 antibody, zgc:110662 antibody, karyopherin subunit alpha 5 antibody, karyopherin alpha 5 (importin alpha 6) antibody, KPNA5 antibody, Kpna5 antibody, kpna5 antibody
    背景
    Synonyms: Background:Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex(NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and-beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.
    分子量
    60 kDa
    基因ID
    3841
    UniProt
    O15131
    途径
    Protein targeting to Nucleus
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