G10P2 antibody, GARG-39 antibody, IFI-54 antibody, IFI-54K antibody, IFI54 antibody, IFIT-2 antibody, ISG-54 K antibody, ISG-54K antibody, ISG54 antibody, P54 antibody, cig42 antibody, wu:fb58d07 antibody, DKFZp468G198 antibody, AV302338 antibody, Ifi54 antibody, interferon induced protein with tetratricopeptide repeats 2 antibody, interferon-induced protein with tetratricopeptide repeats 2 antibody, interferon-induced protein with tetratricopeptide repeats 15 antibody, IFIT2 antibody, Ifit2 antibody, ifit15 antibody
背景
Synonyms:cig42, G10P2, GARG 39, IFI 54, IFI 54K, IFI54, IFIT 2, IFIT2, ISG 54 K, ISG 54K, ISG54 Background:IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation(cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.