HOMER antibody, HOMER1A antibody, HOMER1B antibody, HOMER1C antibody, SYN47 antibody, Ves-1 antibody, HOMER1 antibody, PSD-Zip45 antibody, homer1 antibody, zgc:100854 antibody, zgc:92844 antibody, HOMER1F antibody, Vesl-1 antibody, homer antibody, xhomer1 antibody, BEST:LD03829 antibody, CG11324 antibody, Dhom antibody, Dhomer antibody, Dm Homer antibody, Dmel\CG11324 antibody, Dvh antibody, Hom antibody, Homer antibody, LD03829 antibody, dhom antibody, homer scaffolding protein 1 antibody, homer scaffolding protein 1b antibody, homer scaffolding protein 1 L homeolog antibody, CG11324 gene product from transcript CG11324-RD antibody, HOMER1 antibody, Homer1 antibody, homer1b antibody, homer1.L antibody, homer antibody
背景
Synonyms:SYN47 Background:Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.