HMHA1 抗体
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- 抗原 See all HMHA1 抗体
- HMHA1 (Histocompatibility (Minor) HA-1 (HMHA1))
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适用
- 人, 大鼠, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This HMHA1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95 % as determined by SDS-PAGE
- 免疫原
- histocompatibility(minor) HA-1
- 亚型
- IgG
- Top Product
- Discover our top product HMHA1 Primary Antibody
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anti-Histocompatibility (Minor) HA-1 (HMHA1) (AA 91-190) antibody
HMHA1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4H7 unconjugated
anti-Histocompatibility (Minor) HA-1 (HMHA1) (AA 877-903) antibodyHMHA1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21759 unconjugated
anti-Histocompatibility (Minor) HA-1 (HMHA1) antibodyHMHA1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Histocompatibility (Minor) HA-1 (HMHA1) antibodyHMHA1 适用: 人, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Histocompatibility (Minor) HA-1 (HMHA1) (AA 57-71) antibodyVerified HMHA1 适用: 人 ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
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- 应用备注
- WB: 1:500-1:2000, IHC: 1:20-1:200
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
- 有效期
- 12 months
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- 抗原
- HMHA1 (Histocompatibility (Minor) HA-1 (HMHA1))
- 别名
- HMHA1 (HMHA1 产品)
- 别名
- RGD1308662 antibody, MGC80108 antibody, hmha1 antibody, arhgap45 antibody, ha-1 antibody, HMHA1 antibody, DKFZp469A2018 antibody, ARHGAP45 antibody, HA-1 antibody, HLA-HA1 antibody, 6330406L22Rik antibody, AW539505 antibody, Ha-1 antibody, Rho GTPase activating protein 45 antibody, Rho GTPase activating protein 45 L homeolog antibody, histocompatibility (minor) HA-1 b antibody, Arhgap45 antibody, ARHGAP45 antibody, arhgap45.L antibody, hmha1b antibody, arhgap45 antibody
- 背景
- Synonyms:KIAA0223 Background:GTPase activator for the Rho-type GTPases. Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens(mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease(GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation(BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte(CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL.
- 分子量
- 140-150kd
- 基因ID
- 23526
- UniProt
- Q92619
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