macroH2A2 antibody, RGD1561371 antibody, MGC69037 antibody, MGC130768 antibody, macroh2a2 antibody, im:6898017 antibody, wu:fa14g05 antibody, zgc:114051 antibody, H2AFY2 antibody, H2A histone family member Y2 antibody, H2A histone family, member Y2 antibody, H2A histone family member Y2 L homeolog antibody, core histone macro-H2A.2 antibody, H2AFY2 antibody, H2afy2 antibody, h2afy2.L antibody, h2afy2 antibody, LOC100224559 antibody, LOC100343925 antibody, LOC100456998 antibody, LOC489024 antibody, LOC100738475 antibody
背景
Synonyms:MACROH2A2 Background:Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.