cb244 antibody, fb78f03 antibody, sb:cb244 antibody, im:3814960 antibody, wu:fb78f03 antibody, xell2 antibody, MGC82755 antibody, ELL2 antibody, elongation factor for RNA polymerase II 2 antibody, elongation factor, RNA polymerase II, 2 antibody, elongation factor, RNA polymerase II 2 S homeolog antibody, elongation factor, RNA polymerase II 2 antibody, elongation factor RNA polymerase II 2 antibody, ELL2 antibody, ell2 antibody, ell2.S antibody, Ell2 antibody
背景
Synonyms: Background:Elongation factor component of the super elongation complex(SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex(LEC), a complex required to regulate small nuclear RNA(snRNA) gene transcription by RNA polymerase II and III(PubMed:22195968). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain(IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression.