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BBS5 抗体

BBS5 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7111935
发货至: 中国
  • 抗原 See all BBS5 抗体
    BBS5 (Bardet-Biedl Syndrome 5 (BBS5))
    适用
    • 15
    • 6
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 12
    • 3
    克隆类型
    • 14
    • 1
    多克隆
    标记
    • 12
    • 1
    • 1
    • 1
    This BBS5 antibody is un-conjugated
    应用范围
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
    纯化方法
    Immunogen affinity purified
    纯度
    ≥95 % as determined by SDS-PAGE
    免疫原
    Bardet-Biedl syndrome 5
    亚型
    IgG
    Top Product
    Discover our top product BBS5 Primary Antibody
  • 应用备注
    WB: 1:1000-1:6000, IP: 1:500-1:3000, IHC: 1:50-1:500, IF: 1:50-1:500
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    有效期
    12 months
  • 抗原
    BBS5 (Bardet-Biedl Syndrome 5 (BBS5))
    别名
    BBS5 (BBS5 产品)
    别名
    zgc:56578 antibody, 1700049I01Rik antibody, 2700023J09Rik antibody, Bardet-Biedl syndrome 5 antibody, Bardet-Biedl syndrome 5 (human) antibody, bbs5 antibody, BBS5 antibody, Bbs5 antibody
    背景
    Synonyms: Background:The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor(GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog(SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.
    分子量
    40-45 kDa
    基因ID
    129880
    UniProt
    Q8N3I7
    途径
    Hedgehog Signaling
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