USP7 抗体 (AA 801-897)
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- 抗原 See all USP7 抗体
- USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))
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抗原表位
- AA 801-897
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This USP7 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 预测反应
- Human,Mouse,Rat,Dog,Cow,Pig,Chicken,Rabbit
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human HAUSP/USP7
- 亚型
- IgG
- Top Product
- Discover our top product USP7 Primary Antibody
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anti-Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) (AA 54-507) antibody
USP7 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) antibodyUSP7 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Monoclonal 7F10 unconjugated Recombinant Antibody
anti-Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) (AA 206-1102) antibodyUSP7 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) (AA 206-1102) antibodyUSP7 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) antibodyUSP7 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) (Internal Region) antibodyUSP7 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) (AA 1050-1100) antibodyUSP7 适用: 人, 小鼠, 大鼠, 犬, 马, 小鸡, Macaque WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) (AA 258-483) antibodyUSP7 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) (AA 302-394), (C-Term) antibodyUSP7 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) (AA 30-80) antibodyUSP7 适用: 人, 小鼠, 大鼠, 犬, 马, 小鸡, Macaque WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))
- 别名
- HAUSP (USP7 产品)
- 背景
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Synonyms: TEF1, HAUSP, Ubiquitin carboxyl-terminal hydrolase 7, Deubiquitinating enzyme 7, Herpesvirus-associated ubiquitin-specific protease, Ubiquitin thioesterase 7, Ubiquitin-specific-processing protease 7, USP7
Background: Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6. Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection. Involved in maintenance of DNA methylation via its interaction with UHRF1 and DNMT1: acts by mediating deubiquitination of UHRF1 and DNMT1, preventing their degradation and promoting DNA methylation by DNMT1. Exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Increases regulatory T-cells (Treg) suppressive capacity by deubiquitinating and stabilizing the transcription factor FOXP3 which is crucial for Treg cell function (PubMed:23973222).
- 基因ID
- 7874
- UniProt
- Q93009
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