SREBF chaperone 抗体 (AA 41-140)
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- 抗原 See all SREBF chaperone (SCAP) 抗体
- SREBF chaperone (SCAP)
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抗原表位
- AA 41-140
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This SREBF chaperone antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 预测反应
- Human
- 免疫原
- KLH conjugated synthetic peptide derived from human SCAP
- 克隆位点
- B7T5
- Top Product
- Discover our top product SCAP Primary Antibody
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anti-SREBF chaperone (SCAP) (AA 604-632) antibody
SCAP 适用: 人, 小鼠, 大鼠 WB, IHC (p), FACS, IF 宿主: 兔 Polyclonal RB22508 unconjugated
anti-SREBF chaperone (SCAP) antibodySCAP 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-SREBF chaperone (SCAP) (AA 54-83), (N-Term) antibodySCAP 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB31071 unconjugated
anti-SREBF chaperone (SCAP) antibodySCAP 适用: 人 WB, IHC, FACS, IF/ICC 宿主: 兔 Polyclonal unconjugated
anti-SREBF chaperone (SCAP) (AA 49-83), (N-Term) antibodySCAP 适用: 人 WB 宿主: 小鼠 Monoclonal 1992C245-37-16 unconjugated
anti-SREBF chaperone (SCAP) (AA 977-1194) antibodySCAP 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:300-5000
- 限制
- 仅限研究用
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- 浓度
- 0.5 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- SREBF chaperone (SCAP)
- 别名
- SCAP (SCAP 产品)
- 别名
- 9530044G19 antibody, mKIAA0199 antibody, SREBF chaperone antibody, SREBF chaperone S homeolog antibody, SCAP antibody, Scap antibody, scap.S antibody
- 背景
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Synonyms: KIAA0199, SCAP_HUMAN, SREBF chaperone, SREBF chaperone protein, SREBP cleavage activating protein, SREBP cleavage-activating protein, Sterol regulatory element binding protein cleavage-activating protein, Sterol regulatory element-binding protein cleavage-activating protein.
Background: Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway.
- 基因ID
- 22937
- UniProt
- Q12770
- 途径
- SARS-CoV-2 Protein Interactome
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