B330005D23Rik antibody, FOG-2 antibody, FOG2 antibody, DIH3 antibody, ZC2HC11B antibody, ZNF89B antibody, hFOG-2 antibody, FOG-A antibody, fog2a antibody, zgc:152696 antibody, zinc finger protein, multitype 2 antibody, zinc finger protein, FOG family member 2 antibody, zinc finger protein, FOG family member 2a antibody, Zfpm2 antibody, ZFPM2 antibody, zfpm2a antibody
背景
FOG-2 is the transcriptional cofactors of FOG family . FOG-2 is able to both positively and negatively influence GATA mediated transcription. FOG-2 is predominantly expressed in heart, neurons and gonads, and it preferentially participates in the regulation of GATA-3, GATA-4 and GATA-6. In cardiomyocytes and fibroblasts, FOG-2 inhibits GATA-4 transcriptional activity, yet FOG-2 restores GATA-1 mediated transcription in erythroid cultures deficient in FOG, suggesting that the observed effects of FOG-2 are context specific and vary between cellular systems.