HSKM-B antibody, KMT3C antibody, ZMYND14 antibody, 1110020E07Rik antibody, 4930402C15 antibody, Zmynd14 antibody, smyd2-a antibody, im:7146196 antibody, smyd2 antibody, wu:fc02f02 antibody, zgc:110553 antibody, si:dkey-121j17.3 antibody, zgc:136609 antibody, SET and MYND domain containing 2 antibody, SET and MYND domain containing 2 S homeolog antibody, SET and MYND domain containing 2a antibody, SET and MYND domain containing 2b antibody, SMYD2 antibody, Smyd2 antibody, smyd2.S antibody, smyd2a antibody, smyd2b antibody
背景
Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53.