PLC-L (for PLC-deleted in lung carcinoma) is a PLC family memeber, the expression of which is decreased in small cell lung carcinomas. PLC-L is normally expressed in a variety of fetal and adult organs including the lung. PLC-L is thought to be involved in inositol phospholipid-based intracellular signaling cascade and aberrant expression of PLC-L may contributes to the genesis or progression of human lung carcinoma.