-
- 抗原
- PGC1 alpha + beta
- 适用
- 人, 小鼠, 大鼠
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- 非结合性
-
应用范围
- Western Blotting (WB)
- 交叉反应
- 小鼠, 大鼠
- 纯化方法
- Affinity purification
- 免疫原
- KLH conjugated Synthetic peptide corresponding to Human PGC1alpha+beta
-
anti-PGC1 alpha + beta antibody
适用: 人 WB 宿主: 兔 Monoclonal unconjugated
-
- 应用备注
- WB (H,M,R) 1: 500-1: 1000
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 缓冲液
- PBS, pH 7.4, 0.02 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
-
- 抗原
- PGC1 alpha + beta
- 背景
- PGC-1αis a transcriptional coactivator that regulates the genes involved in energy metabolism. It is the master regulator of mitochondrial biogenesis. This protein interacts with the nuclear receptor PPAR-γ, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element-binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor causing slow-twitch rather than fast-twitch muscle fiber types. Endurance exercise has been shown to activate the PGC-1α gene in human skeletal muscle. Exercise-induced PGC-1αin skeletal muscle increases autophagy and unfolded protein response. PGC-1α protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.
- 分子量
- 91 kDa
- 基因ID
- 19017
- NCBI登录号
- NP_001317680
- UniProt
- Q9UBK2
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