Myosin Binding Subunit 抗体
This anti-Myosin Binding Subunit antibody is a 兔 多克隆 antibody detecting Myosin Binding Subunit in WB. Suitable for 人, 小鼠 和 大鼠.
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Quick Overview for Myosin Binding Subunit 抗体 (ABIN7074731)
抗原
Myosin Binding Subunit (MBS)
适用
人, 小鼠, 大鼠
宿主
兔
克隆类型
多克隆
标记
This Myosin Binding Subunit antibody is un-conjugated
应用范围
Western Blotting (WB)
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交叉反应
- 人, 大鼠
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纯化方法
- Affinity purification
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免疫原
- Recombinant protein corresponding to Mouse Myosin Phosphatase
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anti-Myosin Binding Subunit (MBS) (N-Term) antibody
MBS 适用: 人, 小鼠, 大鼠 WB, FACS 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB (H,M,R) 1: 500-1: 1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS, pH 7.4, 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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- Myosin Binding Subunit (MBS)
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别名
- Myosin Phosphatase
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背景
- Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase.
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分子量
- 130 kDa
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基因ID
- 17931
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NCBI登录号
- NP_082168
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UniProt
- Q9DBR7
抗原
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