LRRC25 is a 305 amino acid protein that contains two LRR repeats. LRRC25 is a single-pass type I membrane protein that is expressed in monocyte-derived dendritic cells (MDDC), granulocytes, monocytes, plasmacytoid dendritic cells (PDC), B-lymphocytes, peripheral blood leukocytes, spleen and bone marrow, with lower levels in lymph nodes, fetal liver, and appendix. LRRC25 may play a role in the activation of cells of innate and acquired immunity.