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H2-AB1 抗体

H2-AB1 适用: 小鼠, 大鼠 IF, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7074228
发货至: 中国
  • 抗原 See all H2-AB1 products
    H2-AB1 (Histocompatibility 2, Class II Antigen A, beta 1 (H2-AB1))
    适用
    小鼠, 大鼠
    宿主
    • 1
    克隆类型
    • 1
    多克隆
    标记
    • 1
    This H2-AB1 antibody is un-conjugated
    应用范围
    • 1
    • 1
    • 1
    Immunofluorescence (IF), Immunohistochemistry (IHC)
    交叉反应
    大鼠
    纯化方法
    Affinity purification
    免疫原
    Recombinant protein corresponding to Mouse H2ab1
  • 应用备注
    IHC/IF (M,R) 1:4000-1:8800
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS, pH 7.4, 0.02 % sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
  • 抗原
    H2-AB1 (Histocompatibility 2, Class II Antigen A, beta 1 (H2-AB1))
    别名
    H2ab1 (H2-AB1 产品)
    别名
    AI845868 antibody, Abeta antibody, H-2Ab antibody, H2-Ab antibody, I-Abeta antibody, IAb antibody, Ia-2 antibody, Ia2 antibody, Rmcs1 antibody, histocompatibility 2, class II antigen A, beta 1 antibody, H2-Ab1 antibody
    背景
    Atypical histone H2A which replaces conventional H2A during late spermatogenesis and is involved in the replacement of histones to protamine in male germ cells . Core component of nucleosome: nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template . Nucleosomes containing H2AB1 only wrap 130 bp of DNA, compared to 147 bp for classical nucleosomes . In condensing spermatids, the heterodimer between H2AB1 and H2BC1/TH2B is loaded onto the nucleosomes and promotes loading of transition proteins (TNP1 and TNP2) onto the nucleosomes . Inclusion of the H2AB1-H2BC1/TH2B dimer into chromatin opens the nucleosomes, releasing the nucleosomal DNA ends and allowing the invasion of nucleosomes by transition proteins (TNP1 and TNP2) .
    基因ID
    68231
    NCBI登录号
    NP_080903
    UniProt
    Q9CQ70
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