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GDF5 抗体

GDF5 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7074131
发货至: 中国
  • 抗原 See all GDF5 抗体
    GDF5 (Growth Differentiation Factor 5 (GDF5))
    适用
    • 74
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    • 18
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    人, 小鼠, 大鼠
    宿主
    • 84
    • 3
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    • 3
    • 1
    克隆类型
    • 88
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    多克隆
    标记
    • 35
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    This GDF5 antibody is un-conjugated
    应用范围
    • 68
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    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    交叉反应
    人, 大鼠
    纯化方法
    Affinity purification
    免疫原
    KLH conjugated Synthetic peptide corresponding to Mouse GDF 5
    Top Product
    Discover our top product GDF5 Primary Antibody
  • 应用备注
    WB (H,M) 1:500-1:1000, IHC/IF (H,R) 1:200-1:400
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS, pH 7.4, 0.02 % sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
  • 抗原
    GDF5 (Growth Differentiation Factor 5 (GDF5))
    别名
    GDF 5 (GDF5 产品)
    别名
    CDMP1 antibody, gdf antibody, gdf-5 antibody, GDF5 antibody, BDA1C antibody, BMP14 antibody, LAP4 antibody, OS5 antibody, SYM1B antibody, SYNS2 antibody, Cdmp-1 antibody, bp antibody, brp antibody, Cdmp1 antibody, growth differentiation factor 5 L homeolog antibody, growth differentiation factor 5 antibody, gdf5.L antibody, GDF5 antibody, Gdf5 antibody
    背景
    Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction . Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG . Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 .
    分子量
    55 kDa
    基因ID
    14563
    NCBI登录号
    NP_032135
    UniProt
    P43027
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