GTF2B 抗体
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- 抗原 See all GTF2B 抗体
- GTF2B (General Transcription Factor IIB (GTF2B))
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This GTF2B antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)
- 交叉反应
- 人, 大鼠
- 纯化方法
- Affinity purification
- 免疫原
- Recombinant protein corresponding to Mouse TFIIB
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- 应用备注
- WB (H,M,R) 1: 500-1: 1000, IHC/IF (H,M,R) 1:500-1:1500/1:500-1:1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS, pH 7.4, 0.02 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
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- 抗原
- GTF2B (General Transcription Factor IIB (GTF2B))
- 别名
- TFIIB (GTF2B 产品)
- 背景
- General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA .Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex .Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle . Associates with chromatin to core promoter- specific regions .Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner,Modulates transcription start site selection . Exhibits also autoacetyltransferase activity that contributes to the activated transcription .
- 分子量
- 35 kDa
- 基因ID
- 229906
- NCBI登录号
- NP_663521
- UniProt
- P62915
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