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EIF2AK1 抗体

EIF2AK1 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7073875
发货至: 中国
  • 抗原 See all EIF2AK1 抗体
    EIF2AK1 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1))
    适用
    • 53
    • 26
    • 14
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    • 1
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    人, 小鼠, 大鼠
    宿主
    • 53
    克隆类型
    • 53
    多克隆
    标记
    • 25
    • 5
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    • 2
    • 2
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    • 2
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    This EIF2AK1 antibody is un-conjugated
    应用范围
    • 32
    • 27
    • 22
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    交叉反应
    人, 大鼠
    纯化方法
    Affinity purification
    免疫原
    Recombinant protein corresponding to Mouse Heme-regulated inhibitor
    Top Product
    Discover our top product EIF2AK1 Primary Antibody
  • 应用备注
    WB (H,M,R) 1 :500-1: 1000, IHC/IF (M,R) 1:800-1:1600/1:500-1:1000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS, pH 7.4, 0.02 % sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
  • 抗原
    EIF2AK1 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1))
    别名
    Heme-regulated inhibitor (EIF2AK1 产品)
    别名
    HCR antibody, Hri antibody, HRI antibody, wu:fj97h09 antibody, zgc:153232 antibody, eukaryotic translation initiation factor 2 alpha kinase 1 antibody, eukaryotic translation initiation factor 2-alpha kinase 1 antibody, eukaryotic translation initiation factor 2 alpha kinase 1 L homeolog antibody, EIF2AK1 antibody, eif2ak1 antibody, Eif2ak1 antibody, eif2ak1.L antibody
    背景
    The Eif2ak1 Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser-51', thus preventing its recycling. Binds hemin forming a 1:1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions. In red blood cells, controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties.
    分子量
    70 kDa
    基因ID
    15467
    NCBI登录号
    NP_038585
    UniProt
    Q9Z2R9
    途径
    Hepatitis C
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