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CYB561 抗体

CYB561 适用: 大鼠 IF, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7073661
发货至: 中国
  • 抗原 See all CYB561 抗体
    CYB561 (Cytochrome B-561 (CYB561))
    适用
    • 12
    • 8
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    大鼠
    宿主
    • 9
    • 3
    克隆类型
    • 9
    • 3
    多克隆
    标记
    • 12
    This CYB561 antibody is un-conjugated
    应用范围
    • 11
    • 2
    • 2
    • 1
    • 1
    • 1
    Immunofluorescence (IF), Immunohistochemistry (IHC)
    交叉反应
    大鼠
    纯化方法
    Affinity purification
    免疫原
    Recombinant protein corresponding to Mouse Pyruvate Dehydrogenase E2
    Top Product
    Discover our top product CYB561 Primary Antibody
  • 应用备注
    IHC/IF (R) 1:500-1:1000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS, pH 7.4, 0.02 % sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
  • 抗原
    CYB561 (Cytochrome B-561 (CYB561))
    别名
    Pyruvate Dehydrogenase E2 (CYB561 产品)
    背景
    This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95 % of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure.
    基因ID
    235339
    UniProt
    Q8BMF4
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