zgc:153556 antibody, 1110039H05Rik antibody, COMM domain containing 4 antibody, COMM domain containing 4 S homeolog antibody, commd4 antibody, commd4.S antibody, COMMD4 antibody, Commd4 antibody
背景
COMMD is a new family of proteins with homology to MURR1, a multifunctional protein that inhibits NFkB. These proteins form multimeric complexes and were identified in a biochemical screen for MURR1-associated factors. The family is defined by the presence of a conserved and unique motif termed the COMM (copper metabolism gene MURR1) domain, which functions as an interface for protein-protein interactions. Down-regulates activation of NF-kappa-B.