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B-Cell Linker 抗体

BLNK 适用: 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7073174
发货至: 中国
  • 抗原 See all B-Cell Linker (BLNK) 抗体
    B-Cell Linker (BLNK)
    适用
    • 108
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    小鼠, 大鼠
    宿主
    • 117
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    • 1
    克隆类型
    • 118
    • 8
    多克隆
    标记
    • 48
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    This B-Cell Linker antibody is un-conjugated
    应用范围
    • 108
    • 52
    • 35
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    • 7
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    Immunohistochemistry (IHC), Immunofluorescence (IF)
    交叉反应
    大鼠
    纯化方法
    Affinity purification
    免疫原
    Recombinant protein corresponding to Mouse BLNK
    Top Product
    Discover our top product BLNK Primary Antibody
  • 应用备注
    IHC/IF (M,R) 1:2500-1:5000/1:1500-1:2500
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS, pH 7.4, 0.02 % sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
  • 抗原
    B-Cell Linker (BLNK)
    别名
    BLNK (BLNK 产品)
    别名
    BLNK antibody, blnk antibody, MGC147045 antibody, BASH antibody, Bca antibody, Ly-57 antibody, Ly57 antibody, Lyw-57 antibody, SLP-65 antibody, AGM4 antibody, BLNK-S antibody, LY57 antibody, SLP65 antibody, bca antibody, B-cell linker antibody, B cell linker antibody, BLNK antibody, blnk antibody, Blnk antibody
    背景
    The function of BLNK was first illustrated in BLNK deficient DT40 cells, a chicken B-cell line, which exhibited an abrogated intracellular calcium mobilisation response and impaired activation of MAP kinases p38, JNK, and to a lesser degree ERK upon B-cell receptor (BCR) activation as compared to wild type DT40 cells. In knockout mice, BLNK deficiency results in a partial block in B-cell development, and in humans BLNK deficiency results in a much more profound block in B-cell development. Linker or adaptor proteins provide mechanisms by which receptors can amplify and regulate downstream effector proteins. The B-cell linker protein is essential for normal B-cell development.
    基因ID
    17060
    NCBI登录号
    NP_032554
    UniProt
    Q9QUN3
    途径
    BCR Signaling
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