ABC31 antibody, EST90757 antibody, MLP2 antibody, MOAT-D antibody, MRP3 antibody, cMOAT2 antibody, 1700019L09Rik antibody, Mlp2 antibody, Mrp3 antibody, ATP binding cassette subfamily C member 3 antibody, ATP-binding cassette, sub-family C (CFTR/MRP), member 3 antibody, ABCC3 antibody, Abcc3 antibody
背景
The protein encoded by this gene is a member of the super family of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes.