Recombinant TWEAK 抗体
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- 抗原 See all TWEAK (TNFSF12) 抗体
- TWEAK (TNFSF12) (Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12))
- 抗体类型
- Recombinant Antibody
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适用
- 小鼠
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宿主
- 兔
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克隆类型
- Chimeric
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标记
- This TWEAK antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS), Blocking Peptide (BP)
- 原理
- Anti-TWEAK [MTW-1], Rabbit IgG, kappa
- 特异性
- This antibody is specific for murine TWEAK. It has been shown not to react with TNF-α, FasL, and TRAIL.
- 产品特性
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Original Species of Ab: Rat
Original Format of Ab: IgG1
- 纯化方法
- Protein A affinity purified
- 免疫原
- This antibody was raised by immunising SD rats with CD8-mTWEAK, a fusion of the human CD8alpha extracellular region to murine TWEAK.
- 克隆位点
- MTW-1
- 亚型
- IgG kappa
- Top Product
- Discover our top product TNFSF12 Primary Antibody
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anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12) (AA 42-123) antibody
TNFSF12 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12) (N-Term) antibodyTNFSF12 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12) antibodyTNFSF12 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12) (AA 49-134) antibodyTNFSF12 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4H3 unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12) (AA 43-149) antibodyTNFSF12 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12) (AA 42-123) antibodyTNFSF12 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12) (AA 94-249) antibodyTNFSF12 适用: 人 ELISA, FACS 宿主: 兔 Monoclonal DM140 unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12) (Pro73) antibodyTNFSF12 适用: 人, 小鼠 WB, IHC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12) (AA 53-249) antibodyTNFSF12 适用: 小鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12) (AA 65-247) antibodyTNFSF12 适用: 人 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- The specificity of this antibody has been confirmed in flow cytometric analysis, where it reacts specifically with mTWEAK-transfected L5178Y cells, and not with parental L5178Y cells or cells transfected with related TNF family members (Nakayama et al, 2003). Additionally, this antibody has been used to assess TWEAK cell surface expression in flow cytometric analysis (Nakayama et al, 2003). This antibody has been shown to block CD8-mTWEAK cytotoxicity against L5178Y cells over-expressing murine Fn14, the TWEAK receptor (Nakayama et al, 2003). When administered to collagen-induced arthritis (CIA) mice, this blocking antibody has been shown to have anti-inflammatory and antiangiogenic effects, with associated improvements to both the clinical and histological manifestations of CIA (Kamata et al, 2006). Additionally, administration of this antibody to denervated mice attenuates denervation-induced skeletal muscle loss (Mittal et al, 2010). Finally, administration of this antibody to CD163-/- mice subject to hind limb ischaemia inhibits the increased perfusion resulting from CD163 deficiency (Akahori et al, 2015).
- 说明
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This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG1 format, for improved compatibility with existing reagents, assays and techniques.
- 限制
- 仅限研究用
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- 浓度
- 1 mg/mL
- 缓冲液
- PBS with 0.02 % Proclin 300.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- 抗原
- TWEAK (TNFSF12) (Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12))
- 别名
- TWEAK (TNFSF12 产品)
- 背景
- CD255, TNFSF12, TNF-related weak inducer of apoptosis, MTW1, MTW 1, Tumor necrosis factor ligand superfamily member 12,
- UniProt
- O54907
- 途径
- Apoptosis
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