Recombinant TAG-72 (Minretumomab Biosimilar) 抗体
适用: 人
FACS, IHC, RIA, WB
宿主: 兔
Chimeric
unconjugated
Recombinant Antibody
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- 抗原 See all TAG-72 (Minretumomab Biosimilar) products
- TAG-72 (Minretumomab Biosimilar)
- 抗体类型
- Recombinant Antibody
- 适用
- 人
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宿主
- 兔
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克隆类型
- Chimeric
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标记
- This TAG-72 (Minretumomab Biosimilar) antibody is un-conjugated
- 应用范围
- Flow Cytometry (FACS), Immunohistochemistry (IHC), Radioimmunoassay (RIA), Western Blotting (WB)
- 原理
- Anti-TAG-72 [Minretumomab (CC49 )], Rabbit IgG, kappa
- 特异性
- This antibody is specific for the disaccharide sialyl Tn epitope of human TAG-72. TAG-72 is expressed on a wide range of human carcinomas, including colorectal cancers.
- 产品特性
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Original Species of Ab: Mouse
Original Format of Ab: IgG1
- 纯化方法
- Protein A affinity purified
- 免疫原
- This antibody was raised by immunising BALB/c mice with TAG-72 purified from LS-174T human carcinoma xenograft.
- 亚型
- IgG kappa
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anti-TAG-72 (Minretumomab Biosimilar) antibody
适用: 人 FACS, IHC, RIA, WB 宿主: 小鼠 Monoclonal unconjugated Recombinant Antibody
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- 应用备注
- The reactivity of this antibody with colon cancer extract and purified TAG-72 has been confirmed in solid-phase radioimmunoassays, and its reactivity with formalin-fixed carcinoma tissue sections confirmed in immunoperoxidase studies (Muraro et al, 1988). In flow cytometric analysis of freshly-isolated human carcinoma cells, this antibody reacts more strongly than the anti-TAG-72 MAb B72.3 (Muraro et al, 1988). Equally, flow cytometric analyses using this antibody have revealed that TAG-72 is expressed by certain haematopoietic cell lines (Nicolet et al, 1997). In western blot analysis, this antibody reacts with TAG-72 (Muraro et al, 1988). A humanised version of this antibody has been shown to be safe and sensitive in detecting recurrent colorectal carcinomas in radioimmunoguided surgery (Agnese et al, 2004), while radioimmunotherapy with an iodine-131-conjugated antibody has been shown to have a significant therapeutic effect on metastatic colon carcinoma in Phase I trials (Divgi et al, 1995).
- 说明
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This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
- 限制
- 仅限研究用
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- 浓度
- 1 mg/mL
- 缓冲液
- PBS with 0.02 % Proclin 300.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- 抗原
- TAG-72 (Minretumomab Biosimilar)
- Abstract
- TAG-72 (Minretumomab Biosimilar) 产品
- 背景
- CA 72-4, Tumor-associated antigen 72, TAG72, Tumor-associated glycoprotein 72
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