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Recombinant TAG-72 (Minretumomab Biosimilar) 抗体

适用: 人 FACS, IHC, RIA, WB 宿主: 小鼠 Monoclonal unconjugated Recombinant Antibody
产品编号 ABIN7072523
发货至: 中国
  • 抗原 See all TAG-72 (Minretumomab Biosimilar) products
    TAG-72 (Minretumomab Biosimilar)
    抗体类型
    Recombinant Antibody
    适用
    宿主
    • 1
    小鼠
    克隆类型
    • 1
    单克隆
    标记
    • 1
    This TAG-72 (Minretumomab Biosimilar) antibody is un-conjugated
    应用范围
    Flow Cytometry (FACS), Immunohistochemistry (IHC), Radioimmunoassay (RIA), Western Blotting (WB)
    原理
    Anti-TAG-72 [Minretumomab (CC49 )], Mouse IgG1, kappa
    特异性
    This antibody is specific for the disaccharide sialyl Tn epitope of human TAG-72. TAG-72 is expressed on a wide range of human carcinomas, including colorectal cancers.
    产品特性

    Original Species of Ab: Mouse

    Original Format of Ab: IgG1

    纯化方法
    Protein A affinity purified
    免疫原
    This antibody was raised by immunising BALB/c mice with TAG-72 purified from LS-174T human carcinoma xenograft.
    亚型
    IgG1 kappa
  • 应用备注
    The reactivity of this antibody with colon cancer extract and purified TAG-72 has been confirmed in solid-phase radioimmunoassays, and its reactivity with formalin-fixed carcinoma tissue sections confirmed in immunoperoxidase studies (Muraro et al, 1988). In flow cytometric analysis of freshly-isolated human carcinoma cells, this antibody reacts more strongly than the anti-TAG-72 MAb B72.3 (Muraro et al, 1988). Equally, flow cytometric analyses using this antibody have revealed that TAG-72 is expressed by certain haematopoietic cell lines (Nicolet et al, 1997). In western blot analysis, this antibody reacts with TAG-72 (Muraro et al, 1988). A humanised version of this antibody has been shown to be safe and sensitive in detecting recurrent colorectal carcinomas in radioimmunoguided surgery (Agnese et al, 2004), while radioimmunotherapy with an iodine-131-conjugated antibody has been shown to have a significant therapeutic effect on metastatic colon carcinoma in Phase I trials (Divgi et al, 1995).
    限制
    仅限研究用
  • 浓度
    1 mg/mL
    缓冲液
    PBS with 0.02 % Proclin 300.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • 抗原
    TAG-72 (Minretumomab Biosimilar)
    Abstract
    TAG-72 (Minretumomab Biosimilar) 产品
    背景
    CA 72-4, Tumor-associated antigen 72, TAG72, Tumor-associated glycoprotein 72
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