Recombinant TNFSF8 抗体
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- 抗原 See all TNFSF8 抗体
- TNFSF8 (Tumor Necrosis Factor (Ligand) Superfamily, Member 8 (TNFSF8))
- 抗体类型
- Recombinant Antibody
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适用
- 小鼠
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宿主
- 大鼠
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克隆类型
- 单克隆
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标记
- This TNFSF8 antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS), Blocking Peptide (BP), Functional Studies (Func)
- 原理
- Anti-CD153 [RM153], Rat IgG2b, kappa
- 特异性
- This antibody is specific for murine CD153, a 40- kDa type II transmembrane protein member of the TNF superfamily. Interaction of CD30 with CD153 plays an important role in T cell activation/costimulation.
- 产品特性
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Original Species of Ab: Rat
Original Format of Ab: IgG2b
- 纯化方法
- Protein A affinity purified
- 免疫原
- This antibody was raised by immunising Sprague Dawley rats with the CHO cells stably transfected with murine CD153 and fusing the splenocytes with P3U1 myeloma cells.
- 克隆位点
- RM153
- 亚型
- IgG2b kappa
- Top Product
- Discover our top product TNFSF8 Primary Antibody
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anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 8 (TNFSF8) (AA 68-231) antibody
TNFSF8 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 8 (TNFSF8) (Internal Region) antibodyTNFSF8 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 8 (TNFSF8) (AA 60-227) antibodyTNFSF8 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 8 (TNFSF8) (AA 153-234) antibodyTNFSF8 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2E11 unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 8 (TNFSF8) (AA 63-234) antibodyTNFSF8 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1E1 unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 8 (TNFSF8) (AA 153-234) antibodyTNFSF8 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 8 (TNFSF8) antibodyTNFSF8 适用: 小鼠 FACS, BP, Func 宿主: 兔 Chimeric RM153 unconjugated Recombinant Antibody
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 8 (TNFSF8) (AA 1-234) antibodyTNFSF8 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 8 (TNFSF8) (AA 55-104) antibodyTNFSF8 适用: 人, 小鼠, Cow, 马, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 8 (TNFSF8) antibodyTNFSF8 适用: 人 ELISA, FACS 宿主: 兔 Monoclonal unconjugated
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- 应用备注
- This antibody has been used in various FACS analyses, for instance, to demonstrate that lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22 (Takatori et al, 2009), and to suggest that CD30 ligand/CD30 plays a critical role in Th17 differentiation in mice (Sun et al, 2010). Importantly, the pharmacological effects of this rat anti-mouse CD153 mAb (clone RM153, IgG2b isotype) have been reported in a number of settings. For example, this antibody has been shown to prevent or delay the spontaneous development of diabetes in non-obese diabetic mice when treatment is initiated in young mice (Chakrabarty et al, 2003), and to prolong the survival of mice in a model of CD4+ T-cell-mediated lethal graft-versus-host disease induced by injection of C57BL/6 cells into MHC class II-only disparate bm12 recipients (Blazar et al, 2004). This antibody has also been used as parts of in vivo functional assays to demonstrate that early CD30 signaling is critical for Treg-mediated acute graft-versus-host disease protection after major MHC-mismatch bone marrow transplantation (Zeiser et al, 2007), and to provide direct evidence that pathogenic memory T cells are amenable to suppression in an antigen-specific manner while identifying CD30 as a molecule that is critical for the regulation of memory T cell responses (Dai et al, 2004).
- 限制
- 仅限研究用
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- 浓度
- 1 mg/mL
- 缓冲液
- PBS with 0.02 % Proclin 300.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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