Recombinant CD70 抗体
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- 抗原 See all CD70 抗体
- CD70 (CD70 Molecule (CD70))
- 抗体类型
- Recombinant Antibody
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适用
- 小鼠
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宿主
- 兔
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克隆类型
- Chimeric
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标记
- This CD70 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Blocking Peptide (BP)
- 原理
- Anti-CD70 [TAN1-6], Rabbit IgG, kappa
- 特异性
- This antibody is specific for murine CD70, a 30-33 kDa type II transmembrane glycoprotein. CD70 is a member of the TNF family and is expressed by activated mouse T and B lymphocytes. Interaction of CD70 with CD27, its ligand on T cells, is important in T-B cell crosstalk and plays a role in costimulation and immune regulation.
- 产品特性
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Original Species of Ab: Rat
Original Format of Ab: IgG2a
- 纯化方法
- Protein A affinity purified
- 免疫原
- This antibody was raised by immunising LOU rats with soluble recombinant CD70:Fc fusion protein
- 克隆位点
- TAN1-6
- 亚型
- IgG kappa
- Top Product
- Discover our top product CD70 Primary Antibody
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anti-CD70 Molecule (CD70) (AA 39-193) antibody
CD70 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-CD70 Molecule (CD70) antibodyCD70 适用: 人 FACS 宿主: 小鼠 Monoclonal Ki-24 unconjugated
anti-CD70 Molecule (CD70) antibody (PE)CD70 适用: 人 FACS 宿主: 小鼠 Monoclonal Ki-24 PE
anti-CD70 Molecule (CD70) (AA 47-191) antibodyCD70 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-CD70 Molecule (CD70) antibodyCD70 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-CD70 Molecule (CD70) (AA 1-193) antibodyCD70 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-CD70 Molecule (CD70) antibodyCD70 适用: 人 WB, FACS 宿主: 兔 Monoclonal unconjugated
anti-CD70 Molecule (CD70) (AA 72-101) antibodyCD70 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-CD70 Molecule (CD70) (AA 64-192) antibodyCD70 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-CD70 Molecule (CD70) antibody (PerCP-Cy5.5)CD70 适用: 小鼠 FACS 宿主: 大鼠 Monoclonal FR70 PerCP-Cy5.5
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- 应用备注
- This antibody has been used in various FACS analyses to reveal a critical role for CD70 in CD8 T cell priming by CD40-licensed antigen-presenting cells (Taraban et al, 2004), to demonstrate the differential requirement for CD70 and CD80/CD86 in dendritic cell-mediated activation of tumor-tolerized CD8 T cells (Bak et al, 2012), to examine how temporal changes in dendritic cell subsets, cross-priming and costimulation via CD70 control CD8(+) T cell responses to influenza (Ballesteros-Tato et al, 2010), and to show that CD70 is downregulated by interaction with CD27 (Kuka et al, 2013). In addition, this antibody has been used in vivo to block the CD70-CD27 interaction as part of the two studies examining how CD70 is critically required for the priming of CD8+ T cells (Taraban et al, 2004, Taraban et al, 2006).
- 说明
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This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG2a format, for improved compatibility with existing reagents, assays and techniques.
- 限制
- 仅限研究用
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- 浓度
- 1 mg/mL
- 缓冲液
- PBS with 0.02 % Proclin 300.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- 抗原
- CD70 (CD70 Molecule (CD70))
- 别名
- CD70 (CD70 产品)
- 背景
- TNFSF7, CD27 ligand, CD27-L, Cd27l, CD27LG, CD70 antigen, Ki-24 antigen, Tnfsf7, tumor necrosis factor (ligand) superfamily, member 7, Tumor necrosis factor ligand superfamily member 7
- UniProt
- O55237
- 途径
- Cancer Immune Checkpoints
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