Recombinant CD80 (Galiximab Biosimilar) 抗体
适用: 人
BR, ELISA, FACS, IHC, IP, WB
宿主: 兔
Chimeric
IDEC-114
unconjugated
Recombinant Antibody
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- 抗原 See all CD80 (Galiximab Biosimilar) products
- CD80 (Galiximab Biosimilar)
- 抗体类型
- Recombinant Antibody
- 适用
- 人
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宿主
- 兔
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克隆类型
- Chimeric
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标记
- This CD80 (Galiximab Biosimilar) antibody is un-conjugated
- 应用范围
- Blocking Reagent (BR), ELISA, Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
- 原理
- Anti-CD80 [IDEC-114 (Galiximab)], Rabbit IgG, lambda
- 特异性
- Galiximab is a primatized mAb which consists of human constant and primate (cynomolgus macaque) variable regions and binds specifically to CD80. CD80 is a surface glycoprotein and a member of the B7 family of costimulatory molecules. CD80 antigen regulates T cell activation (through interacting with CD28 or CD152) and is expressed transiently in antigen-presenting cells, T cells and normal B cells, and expressed consitutively on various subtypes of B-cell lymphomas.
- 产品特性
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Original Species of Ab: Human
Original Format of Ab: IgG1
- 纯化方法
- Protein A affinity purified
- 免疫原
- Galiximab was prepared by immunizing cynomolgus monkeys with recombinant CD80 antigen. The variable regions of the light and heavy chains were then cloned by being incorporated into a cassette vector (N5LG1) containing human constant region genes and subsequently transfected into the Dg44 CHO cell line (Hariharan K, 2013)
- 克隆位点
- IDEC-114
- 亚型
- IgG lambda
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- 应用备注
- Galiximab acts to decrease in cell proliferation, inhibition of the constitutively active NF-κB pathway, increase in apoptosis and ADCC against various B-cell lymphoma cell lines. Galiximb affects CD28 and CD152 interactions with CD80. This antibody can also be used for FC, WB, ELISA, IP and IHC.
- 说明
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This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
- 限制
- 仅限研究用
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- 浓度
- 1 mg/mL
- 缓冲液
- PBS with 0.02 % Proclin 300.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- 抗原
- CD80 (Galiximab Biosimilar)
- Abstract
- CD80 (Galiximab Biosimilar) 产品
- 物质类
- Biosimilar
- 背景
- B7-1, T-lymphocyte activation antigen CD80, Activation B7-1 antigen, BB1, CTLA-4 counter-receptor B7.1, B7
- UniProt
- P33681
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